Partake in a three-day test of strength and determination as you begin your walking journey in historic neighborhoods of Charleston and end on the sandy beaches of Isle of Palms. Walk 50 miles and make a difference in the lives of those affected by multiple sclerosis. Each walker must raise a minimum of $1,500 to participate in this battle against the unpredictable disease. Wild Dunes Resort, 4600 Palm Blvd., Isle of Palms. Friday-Sunday, all day. $75. (800)344-4867, www.challengenct.nationalmssociety.org